Small-Molecule Immunosuppressive Drugs and Therapeutic Immunoglobulins Differentially Inhibit NK Cell Effector Functions in vitro
Identifieur interne : 000427 ( Main/Exploration ); précédent : 000426; suivant : 000428Small-Molecule Immunosuppressive Drugs and Therapeutic Immunoglobulins Differentially Inhibit NK Cell Effector Functions in vitro
Auteurs : Amandine Pradier [Suisse] ; Maria Papaserafeim [Suisse] ; Ning Li [Suisse] ; Anke Rietveld [Suisse] ; Charlotte Kaestel [Suisse] ; Lyssia Gruaz [Suisse] ; Cédric Vonarburg [Suisse] ; Rolf Spirig [Suisse] ; Gisella L. Puga Yung [Suisse] ; Jörg D. Seebach [Suisse]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Small-molecule immunosuppressive drugs (ISD) prevent graft rejection mainly by inhibiting T lymphocytes. Therapeutic immunoglobulins (IVIg) are used for substitution, antibody-mediated rejection (AbMR) and HLA-sensitized recipients by targeting distinct cell types. Since the effect of ISD and IVIg on natural killer (NK) cells remains somewhat controversial in the current literature, the aim of this comparative study was to investigate healthy donor's human NK cell functions after exposure to ISD and IVIg, and to comprehensively review the current literature. NK cells were incubated overnight with IL2/IL12 and different doses and combinations of ISD and IVIg. Proliferation was evaluated by 3[H]-thymidine incorporation; phenotype, degranulation and interferon gamma (IFNγ) production by flow cytometry and ELISA; direct NK cytotoxicity by standard 51[Cr]-release and non-radioactive DELFIA assays using K562 as stimulator and target cells; porcine endothelial cells coated with human anti-pig antibodies were used as targets in antibody-dependent cellular cytotoxicity (ADCC) assays. We found that CD69, CD25, CD54, and NKG2D were downregulated by ISD. Proliferation was inhibited by methylprednisolone (MePRD), mycophenolic acid (MPA), and everolimus (EVE). MePRD and MPA reduced degranulation, MPA only of CD56bright NK cells. MePRD and IVIg inhibited direct cytotoxicity and ADCC. Combinations of ISD demonstrated cumulative inhibitory effects. IFNγ production was inhibited by MePRD and ISD combinations, but not by IVIg. In conclusion, IVIg, ISD and combinations thereof differentially inhibit NK cell functions. The most potent drug with an effect on all NK functions was MePRD. The fact that MePRD and IVIg significantly block NK cytotoxicity, especially ADCC, has major implications for AbMR as well as therapeutic strategies targeting cancer and immune cells with monoclonal antibodies.
Url:
DOI: 10.3389/fimmu.2019.00556
PubMed: 30972058
PubMed Central: 6445861
Affiliations:
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Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Papaserafeim, Maria" sort="Papaserafeim, Maria" uniqKey="Papaserafeim M" first="Maria" last="Papaserafeim">Maria Papaserafeim</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Ning" sort="Li, Ning" uniqKey="Li N" first="Ning" last="Li">Ning Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rietveld, Anke" sort="Rietveld, Anke" uniqKey="Rietveld A" first="Anke" last="Rietveld">Anke Rietveld</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kaestel, Charlotte" sort="Kaestel, Charlotte" uniqKey="Kaestel C" first="Charlotte" last="Kaestel">Charlotte Kaestel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gruaz, Lyssia" sort="Gruaz, Lyssia" uniqKey="Gruaz L" first="Lyssia" last="Gruaz">Lyssia Gruaz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vonarburg, Cedric" sort="Vonarburg, Cedric" uniqKey="Vonarburg C" first="Cédric" last="Vonarburg">Cédric Vonarburg</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CSL Behring AG</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spirig, Rolf" sort="Spirig, Rolf" uniqKey="Spirig R" first="Rolf" last="Spirig">Rolf Spirig</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CSL Behring AG</institution>,<addr-line>Bern</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Puga Yung, Gisella L" sort="Puga Yung, Gisella L" uniqKey="Puga Yung G" first="Gisella L." last="Puga Yung">Gisella L. Puga Yung</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seebach, Jorg D" sort="Seebach, Jorg D" uniqKey="Seebach J" first="Jörg D." last="Seebach">Jörg D. Seebach</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Immunology and Allergy, University Hospitals and Medical Faculty</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Small-molecule immunosuppressive drugs (ISD) prevent graft rejection mainly by inhibiting T lymphocytes. Therapeutic immunoglobulins (IVIg) are used for substitution, antibody-mediated rejection (AbMR) and HLA-sensitized recipients by targeting distinct cell types. Since the effect of ISD and IVIg on natural killer (NK) cells remains somewhat controversial in the current literature, the aim of this comparative study was to investigate healthy donor's human NK cell functions after exposure to ISD and IVIg, and to comprehensively review the current literature. NK cells were incubated overnight with IL2/IL12 and different doses and combinations of ISD and IVIg. Proliferation was evaluated by <sup>3</sup>[H]-thymidine incorporation; phenotype, degranulation and interferon gamma (IFNγ) production by flow cytometry and ELISA; direct NK cytotoxicity by standard <sup>51</sup>[Cr]-release and non-radioactive DELFIA assays using K562 as stimulator and target cells; porcine endothelial cells coated with human anti-pig antibodies were used as targets in antibody-dependent cellular cytotoxicity (ADCC) assays. We found that CD69, CD25, CD54, and NKG2D were downregulated by ISD. Proliferation was inhibited by methylprednisolone (MePRD), mycophenolic acid (MPA), and everolimus (EVE). MePRD and MPA reduced degranulation, MPA only of CD56<sup>bright</sup> NK cells. MePRD and IVIg inhibited direct cytotoxicity and ADCC. Combinations of ISD demonstrated cumulative inhibitory effects. IFNγ production was inhibited by MePRD and ISD combinations, but not by IVIg. In conclusion, IVIg, ISD and combinations thereof differentially inhibit NK cell functions. The most potent drug with an effect on all NK functions was MePRD. The fact that MePRD and IVIg significantly block NK cytotoxicity, especially ADCC, has major implications for AbMR as well as therapeutic strategies targeting cancer and immune cells with monoclonal antibodies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cerwenka, A" uniqKey="Cerwenka A">A Cerwenka</name></author><author><name sortKey="Lanier, Ll" uniqKey="Lanier L">LL Lanier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poli, A" uniqKey="Poli A">A Poli</name></author><author><name sortKey="Michel, T" uniqKey="Michel T">T Michel</name></author><author><name sortKey="Patil, N" uniqKey="Patil N">N Patil</name></author><author><name sortKey="Zimmer, J" uniqKey="Zimmer J">J Zimmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggeri, L" uniqKey="Ruggeri L">L Ruggeri</name></author><author><name sortKey="Capanni, M" uniqKey="Capanni M">M Capanni</name></author><author><name sortKey="Urbani, E" uniqKey="Urbani E">E Urbani</name></author><author><name sortKey="Perruccio, K" uniqKey="Perruccio K">K Perruccio</name></author><author><name sortKey="Shlomchik, Wd" uniqKey="Shlomchik W">WD Shlomchik</name></author><author><name sortKey="Tosti, A" uniqKey="Tosti A">A Tosti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooley, S" uniqKey="Cooley S">S Cooley</name></author><author><name sortKey="Parham, P" uniqKey="Parham P">P Parham</name></author><author><name sortKey="Miller, Js" uniqKey="Miller J">JS Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofer, E" uniqKey="Hofer E">E Hofer</name></author><author><name sortKey="Koehl, U" uniqKey="Koehl U">U Koehl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puga Yung, G" uniqKey="Puga Yung G">G Puga Yung</name></author><author><name sortKey="Schneider, Mkj" uniqKey="Schneider M">MKJ Schneider</name></author><author><name sortKey="Seebach, Jd" uniqKey="Seebach J">JD Seebach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitchens, Wh" uniqKey="Kitchens W">WH Kitchens</name></author><author><name sortKey="Uehara, S" uniqKey="Uehara S">S Uehara</name></author><author><name sortKey="Chase, Cm" uniqKey="Chase C">CM Chase</name></author><author><name sortKey="Colvin, Rb" uniqKey="Colvin R">RB Colvin</name></author><author><name sortKey="Russell, Ps" uniqKey="Russell P">PS Russell</name></author><author><name sortKey="Madsen, Jc" uniqKey="Madsen J">JC Madsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Touw, W" uniqKey="Van Der Touw W">W van der Touw</name></author><author><name sortKey="Bromberg, Js" uniqKey="Bromberg J">JS Bromberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harmon, C" uniqKey="Harmon C">C Harmon</name></author><author><name sortKey="Sanchez Fueyo, A" uniqKey="Sanchez Fueyo A">A Sanchez-Fueyo</name></author><author><name sortKey="O Farrelly, C" uniqKey="O Farrelly C">C O'Farrelly</name></author><author><name sortKey="Houlihan, Dd" uniqKey="Houlihan D">DD Houlihan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Botet, M" uniqKey="Lopez Botet M">M Lopez-Botet</name></author><author><name sortKey="Vilches, C" uniqKey="Vilches C">C Vilches</name></author><author><name sortKey="Redondo Pachon, D" uniqKey="Redondo Pachon D">D Redondo-Pachon</name></author><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Pupuleku, A" uniqKey="Pupuleku A">A Pupuleku</name></author><author><name sortKey="Yelamos, J" uniqKey="Yelamos J">J Yelamos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadad, U" uniqKey="Hadad U">U Hadad</name></author><author><name sortKey="Martinez, O" uniqKey="Martinez O">O Martinez</name></author><author><name sortKey="Krams, Sm" uniqKey="Krams S">SM Krams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hidalgo, Lg" uniqKey="Hidalgo L">LG Hidalgo</name></author><author><name sortKey="Sis, B" uniqKey="Sis B">B Sis</name></author><author><name sortKey="Sellares, J" uniqKey="Sellares J">J Sellares</name></author><author><name sortKey="Campbell, Pm" uniqKey="Campbell P">PM Campbell</name></author><author><name sortKey="Mengel, M" uniqKey="Mengel M">M Mengel</name></author><author><name sortKey="Einecke, G" uniqKey="Einecke G">G Einecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merola, J" uniqKey="Merola J">J Merola</name></author><author><name sortKey="Jane Wit, Dd" uniqKey="Jane Wit D">DD Jane-Wit</name></author><author><name sortKey="Pober, Js" uniqKey="Pober J">JS Pober</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Zx" uniqKey="Zhang Z">ZX Zhang</name></author><author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Lau, A" uniqKey="Lau A">A Lau</name></author><author><name sortKey="Yin, Z" uniqKey="Yin Z">Z Yin</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paul, P" uniqKey="Paul P">P Paul</name></author><author><name sortKey="Picard, C" uniqKey="Picard C">C Picard</name></author><author><name sortKey="Sampol, E" uniqKey="Sampol E">E Sampol</name></author><author><name sortKey="Lyonnet, L" uniqKey="Lyonnet L">L Lyonnet</name></author><author><name sortKey="Di Cristofaro, J" uniqKey="Di Cristofaro J">J Di Cristofaro</name></author><author><name sortKey="Paul Delvaux, L" uniqKey="Paul Delvaux L">L Paul-Delvaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajalingam, R" uniqKey="Rajalingam R">R Rajalingam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Resch, T" uniqKey="Resch T">T Resch</name></author><author><name sortKey="Fabritius, C" uniqKey="Fabritius C">C Fabritius</name></author><author><name sortKey="Ebner, S" uniqKey="Ebner S">S Ebner</name></author><author><name sortKey="Ritschl, P" uniqKey="Ritschl P">P Ritschl</name></author><author><name sortKey="Kotsch, K" uniqKey="Kotsch K">K Kotsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halloran, Pf" uniqKey="Halloran P">PF Halloran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furiasse, N" uniqKey="Furiasse N">N Furiasse</name></author><author><name sortKey="Kobashigawa, Ja" uniqKey="Kobashigawa J">JA Kobashigawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charlton, M" uniqKey="Charlton M">M Charlton</name></author><author><name sortKey="Levitsky, J" uniqKey="Levitsky J">J Levitsky</name></author><author><name sortKey="Aqel, B" uniqKey="Aqel B">B Aqel</name></author><author><name sortKey="O Grady, J" uniqKey="O Grady J">J O'Grady</name></author><author><name sortKey="Hemibach, J" uniqKey="Hemibach J">J Hemibach</name></author><author><name sortKey="Rinella, M" uniqKey="Rinella M">M Rinella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jordan, Sc" uniqKey="Jordan S">SC Jordan</name></author><author><name sortKey="Toyoda, M" uniqKey="Toyoda M">M Toyoda</name></author><author><name sortKey="Kahwaji, J" uniqKey="Kahwaji J">J Kahwaji</name></author><author><name sortKey="Vo, Aa" uniqKey="Vo A">AA Vo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwab, I" uniqKey="Schwab I">I Schwab</name></author><author><name sortKey="Nimmerjahn, F" uniqKey="Nimmerjahn F">F Nimmerjahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tha In, T" uniqKey="Tha In T">T Tha-In</name></author><author><name sortKey="Metselaar, Hj" uniqKey="Metselaar H">HJ Metselaar</name></author><author><name sortKey="Tilanus, Hw" uniqKey="Tilanus H">HW Tilanus</name></author><author><name sortKey="Groothuismink, Zm" uniqKey="Groothuismink Z">ZM Groothuismink</name></author><author><name sortKey="Kuipers, Ej" uniqKey="Kuipers E">EJ Kuipers</name></author><author><name sortKey="De Man, Ra" uniqKey="De Man R">RA de Man</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seebach, Jd" uniqKey="Seebach J">JD Seebach</name></author><author><name sortKey="Comrack, C" uniqKey="Comrack C">C Comrack</name></author><author><name sortKey="Germana, S" uniqKey="Germana S">S Germana</name></author><author><name sortKey="Leguern, C" uniqKey="Leguern C">C Leguern</name></author><author><name sortKey="Sachs, Dh" uniqKey="Sachs D">DH Sachs</name></author><author><name sortKey="Dersimonian, H" uniqKey="Dersimonian H">H DerSimonian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baggio, L" uniqKey="Baggio L">L Baggio</name></author><author><name sortKey="Laureano, Am" uniqKey="Laureano A">AM Laureano</name></author><author><name sortKey="Silla, L" uniqKey="Silla L">L Silla</name></author><author><name sortKey="Lee, Da" uniqKey="Lee D">DA Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Preethy, S" uniqKey="Preethy S">S Preethy</name></author><author><name sortKey="Dedeepiya, Vd" uniqKey="Dedeepiya V">VD Dedeepiya</name></author><author><name sortKey="Senthilkumar, R" uniqKey="Senthilkumar R">R Senthilkumar</name></author><author><name sortKey="Rajmohan, M" uniqKey="Rajmohan M">M Rajmohan</name></author><author><name sortKey="Karthick, R" uniqKey="Karthick R">R Karthick</name></author><author><name sortKey="Terunuma, H" uniqKey="Terunuma H">H Terunuma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madelon, N" uniqKey="Madelon N">N Madelon</name></author><author><name sortKey="Puga Yung, Gl" uniqKey="Puga Yung G">GL Puga Yung</name></author><author><name sortKey="Seebach, Jd" uniqKey="Seebach J">JD Seebach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alter, G" uniqKey="Alter G">G Alter</name></author><author><name sortKey="Malenfant, Jm" uniqKey="Malenfant J">JM Malenfant</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seebach, Jd" uniqKey="Seebach J">JD Seebach</name></author><author><name sortKey="Schneider, Mk" uniqKey="Schneider M">MK Schneider</name></author><author><name sortKey="Comrack, Ca" uniqKey="Comrack C">CA Comrack</name></author><author><name sortKey="Leguern, A" uniqKey="Leguern A">A LeGuern</name></author><author><name sortKey="Kolb, Sa" uniqKey="Kolb S">SA Kolb</name></author><author><name sortKey="Knolle, Pa" uniqKey="Knolle P">PA Knolle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, Bc" uniqKey="Baumann B">BC Baumann</name></author><author><name sortKey="Forte, P" uniqKey="Forte P">P Forte</name></author><author><name sortKey="Hawley, Rj" uniqKey="Hawley R">RJ Hawley</name></author><author><name sortKey="Rieben, R" uniqKey="Rieben R">R Rieben</name></author><author><name sortKey="Schneider, Mk" uniqKey="Schneider M">MK Schneider</name></author><author><name sortKey="Seebach, Jd" uniqKey="Seebach J">JD Seebach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blomberg, K" uniqKey="Blomberg K">K Blomberg</name></author><author><name sortKey="Hautala, R" uniqKey="Hautala R">R Hautala</name></author><author><name sortKey="Lovgren, J" uniqKey="Lovgren J">J Lovgren</name></author><author><name sortKey="Mukkala, Vm" uniqKey="Mukkala V">VM Mukkala</name></author><author><name sortKey="Lindqvist, C" uniqKey="Lindqvist C">C Lindqvist</name></author><author><name sortKey="Akerman, K" uniqKey="Akerman K">K Akerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, Ug" uniqKey="Andersson U">UG Andersson</name></author><author><name sortKey="Bjork, L" uniqKey="Bjork L">L Bjork</name></author><author><name sortKey="Skansen Saphir, U" uniqKey="Skansen Saphir U">U Skansen-Saphir</name></author><author><name sortKey="Andersson, Jp" uniqKey="Andersson J">JP Andersson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tha In, T" uniqKey="Tha In T">T Tha-In</name></author><author><name sortKey="Metselaar, Hj" uniqKey="Metselaar H">HJ Metselaar</name></author><author><name sortKey="Tilanus, Hw" uniqKey="Tilanus H">HW Tilanus</name></author><author><name sortKey="Boor, Pp" uniqKey="Boor P">PP Boor</name></author><author><name sortKey="Mancham, S" uniqKey="Mancham S">S Mancham</name></author><author><name sortKey="Kuipers, Ej" uniqKey="Kuipers E">EJ Kuipers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Ma" uniqKey="Cooper M">MA Cooper</name></author><author><name sortKey="Fehniger, Ta" uniqKey="Fehniger T">TA Fehniger</name></author><author><name sortKey="Caligiuri, Ma" uniqKey="Caligiuri M">MA Caligiuri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fauriat, C" uniqKey="Fauriat C">C Fauriat</name></author><author><name sortKey="Long, Eo" uniqKey="Long E">EO Long</name></author><author><name sortKey="Ljunggren, Hg" uniqKey="Ljunggren H">HG Ljunggren</name></author><author><name sortKey="Bryceson, Yt" uniqKey="Bryceson Y">YT Bryceson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiossone, L" uniqKey="Chiossone L">L Chiossone</name></author><author><name sortKey="Vitale, C" uniqKey="Vitale C">C Vitale</name></author><author><name sortKey="Cottalasso, F" uniqKey="Cottalasso F">F Cottalasso</name></author><author><name sortKey="Moretti, S" uniqKey="Moretti S">S Moretti</name></author><author><name sortKey="Azzarone, B" uniqKey="Azzarone B">B Azzarone</name></author><author><name sortKey="Moretta, L" uniqKey="Moretta L">L Moretta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demmers, Mw" uniqKey="Demmers M">MW Demmers</name></author><author><name sortKey="Korevaar, Ss" uniqKey="Korevaar S">SS Korevaar</name></author><author><name sortKey="Betjes, Mg" uniqKey="Betjes M">MG Betjes</name></author><author><name sortKey="Weimar, W" uniqKey="Weimar W">W Weimar</name></author><author><name sortKey="Rowshani, At" uniqKey="Rowshani A">AT Rowshani</name></author><author><name sortKey="Baan, Cc" uniqKey="Baan C">CC Baan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eissens, Dn" uniqKey="Eissens D">DN Eissens</name></author><author><name sortKey="Van Der, Ma" uniqKey="Van Der M">MA Van Der</name></author><author><name sortKey="Van, Cb" uniqKey="Van C">CB Van</name></author><author><name sortKey="Preijers, Fw" uniqKey="Preijers F">FW Preijers</name></author><author><name sortKey="Joosten, I" uniqKey="Joosten I">I Joosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thum, My" uniqKey="Thum M">MY Thum</name></author><author><name sortKey="Bhaskaran, S" uniqKey="Bhaskaran S">S Bhaskaran</name></author><author><name sortKey="Abdalla, Hi" uniqKey="Abdalla H">HI Abdalla</name></author><author><name sortKey="Ford, B" uniqKey="Ford B">B Ford</name></author><author><name sortKey="Sumar, N" uniqKey="Sumar N">N Sumar</name></author><author><name sortKey="Bansal, A" uniqKey="Bansal A">A Bansal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitale, C" uniqKey="Vitale C">C Vitale</name></author><author><name sortKey="Chiossone, L" uniqKey="Chiossone L">L Chiossone</name></author><author><name sortKey="Cantoni, C" uniqKey="Cantoni C">C Cantoni</name></author><author><name sortKey="Morreale, G" uniqKey="Morreale G">G Morreale</name></author><author><name sortKey="Cottalasso, F" uniqKey="Cottalasso F">F Cottalasso</name></author><author><name sortKey="Moretti, S" uniqKey="Moretti S">S Moretti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Grzywacz, B" uniqKey="Grzywacz B">B Grzywacz</name></author><author><name sortKey="Sukovich, D" uniqKey="Sukovich D">D Sukovich</name></author><author><name sortKey="Mccullar, V" uniqKey="Mccullar V">V McCullar</name></author><author><name sortKey="Cao, Q" uniqKey="Cao Q">Q Cao</name></author><author><name sortKey="Lee, Ab" uniqKey="Lee A">AB Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohata, K" uniqKey="Ohata K">K Ohata</name></author><author><name sortKey="Espinoza, Jl" uniqKey="Espinoza J">JL Espinoza</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Kondo, Y" uniqKey="Kondo Y">Y Kondo</name></author><author><name sortKey="Nakao, S" uniqKey="Nakao S">S Nakao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohira, M" uniqKey="Ohira M">M Ohira</name></author><author><name sortKey="Nishida, S" uniqKey="Nishida S">S Nishida</name></author><author><name sortKey="Tryphonopoulos, P" uniqKey="Tryphonopoulos P">P Tryphonopoulos</name></author><author><name sortKey="Ruiz, P" uniqKey="Ruiz P">P Ruiz</name></author><author><name sortKey="Ohdan, H" uniqKey="Ohdan H">H Ohdan</name></author><author><name sortKey="Tzakis, Ag" uniqKey="Tzakis A">AG Tzakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulica, A" uniqKey="Sulica A">A Sulica</name></author><author><name sortKey="Metes, D" uniqKey="Metes D">D Metes</name></author><author><name sortKey="Gherman, M" uniqKey="Gherman M">M Gherman</name></author><author><name sortKey="Whiteside, Tl" uniqKey="Whiteside T">TL Whiteside</name></author><author><name sortKey="Herberman, Rb" uniqKey="Herberman R">RB Herberman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Tj" uniqKey="Kim T">TJ Kim</name></author><author><name sortKey="Kim, N" uniqKey="Kim N">N Kim</name></author><author><name sortKey="Kang, Hj" uniqKey="Kang H">HJ Kang</name></author><author><name sortKey="Kim, Eo" uniqKey="Kim E">EO Kim</name></author><author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name></author><author><name sortKey="Ahn, Hs" uniqKey="Ahn H">HS Ahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neudoerfl, C" uniqKey="Neudoerfl C">C Neudoerfl</name></author><author><name sortKey="Mueller, Bj" uniqKey="Mueller B">BJ Mueller</name></author><author><name sortKey="Blume, C" uniqKey="Blume C">C Blume</name></author><author><name sortKey="Daemen, K" uniqKey="Daemen K">K Daemen</name></author><author><name sortKey="Stevanovic Meyer, M" uniqKey="Stevanovic Meyer M">M Stevanovic-Meyer</name></author><author><name sortKey="Keil, J" uniqKey="Keil J">J Keil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vacher Coponat, H" uniqKey="Vacher Coponat H">H Vacher-Coponat</name></author><author><name sortKey="Brunet, C" uniqKey="Brunet C">C Brunet</name></author><author><name sortKey="Moal, V" uniqKey="Moal V">V Moal</name></author><author><name sortKey="Loundou, A" uniqKey="Loundou A">A Loundou</name></author><author><name sortKey="Bonnet, E" uniqKey="Bonnet E">E Bonnet</name></author><author><name sortKey="Lyonnet, L" uniqKey="Lyonnet L">L Lyonnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meehan, Ac" uniqKey="Meehan A">AC Meehan</name></author><author><name sortKey="Mifsud, Na" uniqKey="Mifsud N">NA Mifsud</name></author><author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name></author><author><name sortKey="Levvey, Bj" uniqKey="Levvey B">BJ Levvey</name></author><author><name sortKey="Snell, Gi" uniqKey="Snell G">GI Snell</name></author><author><name sortKey="Kotsimbos, Tc" uniqKey="Kotsimbos T">TC Kotsimbos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morteau, O" uniqKey="Morteau O">O Morteau</name></author><author><name sortKey="Blundell, S" uniqKey="Blundell S">S Blundell</name></author><author><name sortKey="Chakera, A" uniqKey="Chakera A">A Chakera</name></author><author><name sortKey="Bennett, S" uniqKey="Bennett S">S Bennett</name></author><author><name sortKey="Christou, Cm" uniqKey="Christou C">CM Christou</name></author><author><name sortKey="Mason, Pd" uniqKey="Mason P">PD Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dugast, E" uniqKey="Dugast E">E Dugast</name></author><author><name sortKey="David, G" uniqKey="David G">G David</name></author><author><name sortKey="Oger, R" uniqKey="Oger R">R Oger</name></author><author><name sortKey="Danger, R" uniqKey="Danger R">R Danger</name></author><author><name sortKey="Judor, Jp" uniqKey="Judor J">JP Judor</name></author><author><name sortKey="Gagne, K" uniqKey="Gagne K">K Gagne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diaz Molina, B" uniqKey="Diaz Molina B">B Diaz-Molina</name></author><author><name sortKey="Diaz Bulnes, P" uniqKey="Diaz Bulnes P">P Diaz-Bulnes</name></author><author><name sortKey="Carvajal Palao, R" uniqKey="Carvajal Palao R">R Carvajal Palao</name></author><author><name sortKey="Bernardo, Mj" uniqKey="Bernardo M">MJ Bernardo</name></author><author><name sortKey="Rodriguez, Rm" uniqKey="Rodriguez R">RM Rodriguez</name></author><author><name sortKey="Corte Iglesias, V" uniqKey="Corte Iglesias V">V Corte-Iglesias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brehm, C" uniqKey="Brehm C">C Brehm</name></author><author><name sortKey="Huenecke, S" uniqKey="Huenecke S">S Huenecke</name></author><author><name sortKey="Esser, R" uniqKey="Esser R">R Esser</name></author><author><name sortKey="Kloess, S" uniqKey="Kloess S">S Kloess</name></author><author><name sortKey="Quaiser, A" uniqKey="Quaiser A">A Quaiser</name></author><author><name sortKey="Betz, S" uniqKey="Betz S">S Betz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoogduijn, Mj" uniqKey="Hoogduijn M">MJ Hoogduijn</name></author><author><name sortKey="Roemeling Van Rhijn, M" uniqKey="Roemeling Van Rhijn M">M Roemeling-van Rhijn</name></author><author><name sortKey="Korevaar, Ss" uniqKey="Korevaar S">SS Korevaar</name></author><author><name sortKey="Engela, Au" uniqKey="Engela A">AU Engela</name></author><author><name sortKey="Weimar, W" uniqKey="Weimar W">W Weimar</name></author><author><name sortKey="Baan, Cc" uniqKey="Baan C">CC Baan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobi, C" uniqKey="Jacobi C">C Jacobi</name></author><author><name sortKey="Claus, M" uniqKey="Claus M">M Claus</name></author><author><name sortKey="Wildemann, B" uniqKey="Wildemann B">B Wildemann</name></author><author><name sortKey="Wingert, S" uniqKey="Wingert S">S Wingert</name></author><author><name sortKey="Korporal, M" uniqKey="Korporal M">M Korporal</name></author><author><name sortKey="Romisch, J" uniqKey="Romisch J">J Romisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rose, Al" uniqKey="Rose A">AL Rose</name></author><author><name sortKey="Smith, Be" uniqKey="Smith B">BE Smith</name></author><author><name sortKey="Maloney, Dg" uniqKey="Maloney D">DG Maloney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Bh" uniqKey="Shin B">BH Shin</name></author><author><name sortKey="Ge, S" uniqKey="Ge S">S Ge</name></author><author><name sortKey="Mirocha, J" uniqKey="Mirocha J">J Mirocha</name></author><author><name sortKey="Karasyov, A" uniqKey="Karasyov A">A Karasyov</name></author><author><name sortKey="Vo, A" uniqKey="Vo A">A Vo</name></author><author><name sortKey="Jordan, Sc" uniqKey="Jordan S">SC Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumai, T" uniqKey="Kumai T">T Kumai</name></author><author><name sortKey="Oikawa, K" uniqKey="Oikawa K">K Oikawa</name></author><author><name sortKey="Aoki, N" uniqKey="Aoki N">N Aoki</name></author><author><name sortKey="Kimura, S" uniqKey="Kimura S">S Kimura</name></author><author><name sortKey="Harabuchi, Y" uniqKey="Harabuchi Y">Y Harabuchi</name></author><author><name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H Kobayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, U" uniqKey="Hoffmann U">U Hoffmann</name></author><author><name sortKey="Neudorfl, C" uniqKey="Neudorfl C">C Neudorfl</name></author><author><name sortKey="Daemen, K" uniqKey="Daemen K">K Daemen</name></author><author><name sortKey="Keil, J" uniqKey="Keil J">J Keil</name></author><author><name sortKey="Stevanovic Meyer, M" uniqKey="Stevanovic Meyer M">M Stevanovic-Meyer</name></author><author><name sortKey="Lehner, F" uniqKey="Lehner F">F Lehner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derniame, S" uniqKey="Derniame S">S Derniame</name></author><author><name sortKey="Perazzo, J" uniqKey="Perazzo J">J Perazzo</name></author><author><name sortKey="Lee, F" uniqKey="Lee F">F Lee</name></author><author><name sortKey="Domogala, A" uniqKey="Domogala A">A Domogala</name></author><author><name sortKey="Escobedo Cousin, M" uniqKey="Escobedo Cousin M">M Escobedo-Cousin</name></author><author><name sortKey="Alnabhan, R" uniqKey="Alnabhan R">R Alnabhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Introna, M" uniqKey="Introna M">M Introna</name></author><author><name sortKey="Allavena, P" uniqKey="Allavena P">P Allavena</name></author><author><name sortKey="Spreafico, F" uniqKey="Spreafico F">F Spreafico</name></author><author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pores Fernando, At" uniqKey="Pores Fernando A">AT Pores-Fernando</name></author><author><name sortKey="Gaur, S" uniqKey="Gaur S">S Gaur</name></author><author><name sortKey="Doyon, My" uniqKey="Doyon M">MY Doyon</name></author><author><name sortKey="Zweifach, A" uniqKey="Zweifach A">A Zweifach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wai, Le" uniqKey="Wai L">LE Wai</name></author><author><name sortKey="Fujiki, M" uniqKey="Fujiki M">M Fujiki</name></author><author><name sortKey="Takeda, S" uniqKey="Takeda S">S Takeda</name></author><author><name sortKey="Martinez, Om" uniqKey="Martinez O">OM Martinez</name></author><author><name sortKey="Krams, Sm" uniqKey="Krams S">SM Krams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watzl, C" uniqKey="Watzl C">C Watzl</name></author><author><name sortKey="Long, Eo" uniqKey="Long E">EO Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ussat, S" uniqKey="Ussat S">S Ussat</name></author><author><name sortKey="Scherer, G" uniqKey="Scherer G">G Scherer</name></author><author><name sortKey="Fazio, J" uniqKey="Fazio J">J Fazio</name></author><author><name sortKey="Beetz, S" uniqKey="Beetz S">S Beetz</name></author><author><name sortKey="Kabelitz, D" uniqKey="Kabelitz D">D Kabelitz</name></author><author><name sortKey="Adam Klages, S" uniqKey="Adam Klages S">S Adam-Klages</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinet, L" uniqKey="Martinet L">L Martinet</name></author><author><name sortKey="Smyth, Mj" uniqKey="Smyth M">MJ Smyth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz, Je" uniqKey="Ruiz J">JE Ruiz</name></author><author><name sortKey="Kwak, Jy" uniqKey="Kwak J">JY Kwak</name></author><author><name sortKey="Baum, L" uniqKey="Baum L">L Baum</name></author><author><name sortKey="Gilman Sachs, A" uniqKey="Gilman Sachs A">A Gilman-Sachs</name></author><author><name sortKey="Beaman, Kd" uniqKey="Beaman K">KD Beaman</name></author><author><name sortKey="Kim, Yb" uniqKey="Kim Y">YB Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engelhard, D" uniqKey="Engelhard D">D Engelhard</name></author><author><name sortKey="Waner, Jl" uniqKey="Waner J">JL Waner</name></author><author><name sortKey="Kapoor, N" uniqKey="Kapoor N">N Kapoor</name></author><author><name sortKey="Good, Ra" uniqKey="Good R">RA Good</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz De Souza, V" uniqKey="Ruiz De Souza V">V Ruiz de Souza</name></author><author><name sortKey="Carreno, Mp" uniqKey="Carreno M">MP Carreno</name></author><author><name sortKey="Kaveri, Sv" uniqKey="Kaveri S">SV Kaveri</name></author><author><name sortKey="Ledur, A" uniqKey="Ledur A">A Ledur</name></author><author><name sortKey="Sadeghi, H" uniqKey="Sadeghi H">H Sadeghi</name></author><author><name sortKey="Cavaillon, Jm" uniqKey="Cavaillon J">JM Cavaillon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ling, Zd" uniqKey="Ling Z">ZD Ling</name></author><author><name sortKey="Yeoh, E" uniqKey="Yeoh E">E Yeoh</name></author><author><name sortKey="Webb, Bt" uniqKey="Webb B">BT Webb</name></author><author><name sortKey="Farrell, K" uniqKey="Farrell K">K Farrell</name></author><author><name sortKey="Doucette, J" uniqKey="Doucette J">J Doucette</name></author><author><name sortKey="Matheson, Ds" uniqKey="Matheson D">DS Matheson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bryceson, Yt" uniqKey="Bryceson Y">YT Bryceson</name></author><author><name sortKey="Chiang, Sc" uniqKey="Chiang S">SC Chiang</name></author><author><name sortKey="Darmanin, S" uniqKey="Darmanin S">S Darmanin</name></author><author><name sortKey="Fauriat, C" uniqKey="Fauriat C">C Fauriat</name></author><author><name sortKey="Schlums, H" uniqKey="Schlums H">H Schlums</name></author><author><name sortKey="Theorell, J" uniqKey="Theorell J">J Theorell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, M" uniqKey="Berg M">M Berg</name></author><author><name sortKey="Lundqvist, A" uniqKey="Lundqvist A">A Lundqvist</name></author><author><name sortKey="Mccoy, P" uniqKey="Mccoy P">P McCoy</name></author><author><name sortKey="Samsel, L" uniqKey="Samsel L">L Samsel</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y Fan</name></author><author><name sortKey="Tawab, A" uniqKey="Tawab A">A Tawab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hietakangas, V" uniqKey="Hietakangas V">V Hietakangas</name></author><author><name sortKey="Poukkula, M" uniqKey="Poukkula M">M Poukkula</name></author><author><name sortKey="Heiskanen, Km" uniqKey="Heiskanen K">KM Heiskanen</name></author><author><name sortKey="Karvinen, Jt" uniqKey="Karvinen J">JT Karvinen</name></author><author><name sortKey="Sistonen, L" uniqKey="Sistonen L">L Sistonen</name></author><author><name sortKey="Eriksson, Je" uniqKey="Eriksson J">JE Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, C" uniqKey="Muller C">C Muller</name></author><author><name sortKey="Schernthaner, G" uniqKey="Schernthaner G">G Schernthaner</name></author><author><name sortKey="Kovarik, J" uniqKey="Kovarik J">J Kovarik</name></author><author><name sortKey="Kalinowska, W" uniqKey="Kalinowska W">W Kalinowska</name></author><author><name sortKey="Zielinski, Cc" uniqKey="Zielinski C">CC Zielinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prince, He" uniqKey="Prince H">HE Prince</name></author><author><name sortKey="Ettenger, Rb" uniqKey="Ettenger R">RB Ettenger</name></author><author><name sortKey="Dorey, Fj" uniqKey="Dorey F">FJ Dorey</name></author><author><name sortKey="Fine, Rn" uniqKey="Fine R">RN Fine</name></author><author><name sortKey="Fahey, Jl" uniqKey="Fahey J">JL Fahey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matheson, Ds" uniqKey="Matheson D">DS Matheson</name></author><author><name sortKey="Green, B" uniqKey="Green B">B Green</name></author><author><name sortKey="Hoar, Di" uniqKey="Hoar D">DI Hoar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakarai, T" uniqKey="Nakarai T">T Nakarai</name></author><author><name sortKey="Ueno, Y" uniqKey="Ueno Y">Y Ueno</name></author><author><name sortKey="Ueno, Y" uniqKey="Ueno Y">Y Ueno</name></author><author><name sortKey="Koizumi, S" uniqKey="Koizumi S">S Koizumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrante, A" uniqKey="Ferrante A">A Ferrante</name></author><author><name sortKey="Goh, Dh" uniqKey="Goh D">DH Goh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishimura, M" uniqKey="Nishimura M">M Nishimura</name></author><author><name sortKey="Hidaka, N" uniqKey="Hidaka N">N Hidaka</name></author><author><name sortKey="Akaza, T" uniqKey="Akaza T">T Akaza</name></author><author><name sortKey="Tadokoro, K" uniqKey="Tadokoro K">K Tadokoro</name></author><author><name sortKey="Juji, T" uniqKey="Juji T">T Juji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Jaderi, Z" uniqKey="Al Jaderi Z">Z Al-Jaderi</name></author><author><name sortKey="Maghazachi, Aa" uniqKey="Maghazachi A">AA Maghazachi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Bh" uniqKey="Shin B">BH Shin</name></author><author><name sortKey="Ge, S" uniqKey="Ge S">S Ge</name></author><author><name sortKey="Mirocha, J" uniqKey="Mirocha J">J Mirocha</name></author><author><name sortKey="Jordan, Sc" uniqKey="Jordan S">SC Jordan</name></author><author><name sortKey="Toyoda, M" uniqKey="Toyoda M">M Toyoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nocturne, G" uniqKey="Nocturne G">G Nocturne</name></author><author><name sortKey="Boudaoud, S" uniqKey="Boudaoud S">S Boudaoud</name></author><author><name sortKey="Ly, B" uniqKey="Ly B">B Ly</name></author><author><name sortKey="Pascaud, J" uniqKey="Pascaud J">J Pascaud</name></author><author><name sortKey="Paoletti, A" uniqKey="Paoletti A">A Paoletti</name></author><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merkt, W" uniqKey="Merkt W">W Merkt</name></author><author><name sortKey="Lorenz, Hm" uniqKey="Lorenz H">HM Lorenz</name></author><author><name sortKey="Watzl, C" uniqKey="Watzl C">C Watzl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hassenruck, F" uniqKey="Hassenruck F">F Hassenruck</name></author><author><name sortKey="Knodgen, E" uniqKey="Knodgen E">E Knodgen</name></author><author><name sortKey="Gockeritz, E" uniqKey="Gockeritz E">E Gockeritz</name></author><author><name sortKey="Midda, Sh" uniqKey="Midda S">SH Midda</name></author><author><name sortKey="Vondey, V" uniqKey="Vondey V">V Vondey</name></author><author><name sortKey="Neumann, L" uniqKey="Neumann L">L Neumann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Pradier, Amandine" sort="Pradier, Amandine" uniqKey="Pradier A" first="Amandine" last="Pradier">Amandine Pradier</name></noRegion><name sortKey="Gruaz, Lyssia" sort="Gruaz, Lyssia" uniqKey="Gruaz L" first="Lyssia" last="Gruaz">Lyssia Gruaz</name><name sortKey="Kaestel, Charlotte" sort="Kaestel, Charlotte" uniqKey="Kaestel C" first="Charlotte" last="Kaestel">Charlotte Kaestel</name><name sortKey="Li, Ning" sort="Li, Ning" uniqKey="Li N" first="Ning" last="Li">Ning Li</name><name sortKey="Papaserafeim, Maria" sort="Papaserafeim, Maria" uniqKey="Papaserafeim M" first="Maria" last="Papaserafeim">Maria Papaserafeim</name><name sortKey="Puga Yung, Gisella L" sort="Puga Yung, Gisella L" uniqKey="Puga Yung G" first="Gisella L." last="Puga Yung">Gisella L. Puga Yung</name><name sortKey="Rietveld, Anke" sort="Rietveld, Anke" uniqKey="Rietveld A" first="Anke" last="Rietveld">Anke Rietveld</name><name sortKey="Seebach, Jorg D" sort="Seebach, Jorg D" uniqKey="Seebach J" first="Jörg D." last="Seebach">Jörg D. Seebach</name><name sortKey="Spirig, Rolf" sort="Spirig, Rolf" uniqKey="Spirig R" first="Rolf" last="Spirig">Rolf Spirig</name><name sortKey="Vonarburg, Cedric" sort="Vonarburg, Cedric" uniqKey="Vonarburg C" first="Cédric" last="Vonarburg">Cédric Vonarburg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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